As with earlier versions of DM, you can if you want configure various basic aspects of Nuxeo DM 5.4 by simply editing the configuration file bin/nuxeo.conf, then restarting your DM session. As described in the earlier section on Getting started with Nuxeo DM 5.4, one of the first settings you might need to change is the default HTTP server port of 8080, in case some other process is already using that port. As for other settings you might want to play with, you can find a fairly complete list of nuxeo.conf variables and their meanings here. But we're not done yet; there's one more important issue we need to cover.
There is one particular set of configuration settings you might want to examine closely, and these are the settings that reflect the locations of things like the log files, DM's "temp" directory, the PID directory and so on. As you might recall, if you install Nuxeo DM 5.4 normally, the entire package is unloaded and installed into a single directory, and while this makes it convenient to totally delete an entire DM install if you want to re-install from scratch, it's not that convenient if you, for some reason, wanted to preserve any of that old information. So you might want to look through the nuxeo.conf configuration file and decide if you want any of that DM information stored externally to your installation directory so you can hang onto it across installs.
Finally, there is one file that you might very well want to preserve across installs, and that's the nuxeo.conf configuration file itself. Since its default location is under DM's bin directory, it will (like all the other files) disappear if you remove the DM install entirely, so you can copy it to another location such as /etc/nuxeo.conf, at which point you'll need to invoke your DM session explicitiy with the new location of that config file, as in: